Why is Dr. Stephen Blake smiling so big?
CBD oil is here and NOW!
Finally my dream is coming true and Big Pharma has some competition that will NOT go away. The time has come for us all to take control of our health and FREE ourselves from Drugs, Chemicals and Vaccines FOREVER.
Here is the latest information on the
use of CBD oil in Dogs and Cats as of
April 14, 2020.
CURRENT INFORMATION THE USE OF CBD OILS IN DOGS AND CATS.
Current CBD dosage recommendations
General dosage 0.1 to 2 mg/Kg. twice per day
Epilepsy or seizures 0.5 to 2.5 mg/Kg twice per day
Pain management 0.5 to 2mg/Kg twice per day
• Two experts in cannabidiol for pets attended a veterinary conference recently and offered attendees some much needed, very insightful information and updates on the growing use of CBD in dogs and cats
• Veterinarian Dr. Robert Silver and Stephen Cital, co-founder of the Veterinary Cannabis Academy, discussed the latest on CBD dosing and routes of administration in pets, CBD and pain relief, and CBD and seizures
• Other topics covered included CBD as a treatment for pets with cancer, side effects of CBD, and choosing a high-quality CBD product
Many of you pet parents out there may know from personal experience the level of confusion that exists in the veterinary community around cannabidiol (CBD) products for pets. In fact, many veterinarians are reluctant to even discuss the topic with their clients for legal reasons and because at the present time, there are many more questions than answers with regard to the effectiveness of CBD in veterinary patients with the variety of products on the market.
Research into CBD for dogs and cats is happening, but as veterinary journal dvm360 describes the situation:
“… research data is not what most veterinarians want to hear. They want to know about clinical usage. Unfortunately, the data is not yet translatable into reliable clinical information for all the claims made.
While over 23,000 scientific papers on cannabinoids in humans, lab animals and companion animals in 24 different species have been published, the jury is still out on exactly what CBD products are effective for and what they are not.”1
However, despite the reticence of the veterinary community to consider the use of cannabidiol, CBD products for dogs and cats are flooding the market as increasing numbers of pet parents search for nontoxic remedies for pain and other conditions in their animal companions.
I feel it’s extremely important that my veterinary colleagues take an active role to address their confusion and distrust around CBD. Many integrative practitioners, including me, have found this herbal remedy extremely beneficial in treating a multitude of medical and behavioral issues in our patients, and feel more pets should be provided the opportunity to experience those benefits as well.
Thankfully, my friend and colleague Dr. Rob Silver, author of “Medical Marijuana and Your Pet,” chief medical officer for Rx Vitamins for Pets, and a small animal veterinarian in Colorado, was invited to speak at a 2019 conference of conventional veterinarians about his experience and knowledge of CBD, including case-based information on its use in veterinary medicine.
But before we get into that, it’s important to have a basic understanding of CBD and its function in the body.
CBD and the Endocannabinoid System
CBD is a cannabinoid containing naturally occurring chemicals that act on the brain and body. The oil is produced from the cannabis plant and has no psychoactive properties like the THC (tetrahydrocannabinol) found in marijuana. Since it’s considered to have a wider range of medical benefits than THC, it can be a win-win for pets.
CBD is extracted from cannabis plants and processed as an isolate or as a full-spectrum oil combined with other related cannabinoids. CBD oils made with full-spectrum extracts are thought to have superior therapeutic effects vs. cannabidiol-only oil.
There are two common strains of cannabis in use today — hemp and marijuana. Hemp is a cannabis plant that contains less than 0.3 percent of THC; marijuana has more than 0.3 percent. CBD products for pets are typically sourced from hemp.
Humans, dogs, cats, and all creatures with a spinal column have an endocannabinoid system (ECS). The ECS was discovered fairly recently and named for the Cannabis sativa L. plant species due to the plant’s ability to dramatically effect it. According to dvm360:
“… the body makes its own (endo)cannabinoids as part of the nervous system, or at least as a partner to it. There are cannabinoid receptors in the brain, heart, lungs, liver, spleen, intestinal tract, muscles, bone, reproductive system and circulatory system, among others. There is some evidence to suggest that the endocannabinoid system is responsible for the ‘runner’s high’ in people.”
The job of the ECS is to regulate functions such as eating, sleeping, relaxing, protecting, and forgetting by maintaining homeostasis via activators and receptors located in the central nervous system and immune system.
Cannabinoids function as messengers for the ECS, and according to Bark magazine, “… their effects depend on the receptors to which they bind. This is a very specific process; a receptor will only accept the particular compound for which it exists, and is unaffected by others.”2
Latest Info on CBD Dosing and Administration in Dogs and Cats
Before study results began to appear, the generally accepted therapeutic dose range for CBD in pets was 0.1 to 0.5 mg/kg twice daily, but according to Dr. Silver and Stephen Cital, co-founder of the Veterinary Cannabis Academy and director of education and development for ElleVet Sciences, it’s safe to go as high as 5 mg/kg twice daily.
A 2018 Cornell study actually shows that dosing as high as 8 mg/kg is safe,3 however, according to Cital, this dosage is neither cost-effective nor practical. He also notes that dosing range guidance has been updated to 0.1 to 2 mg/kg twice daily for dogs and cats based on the most recent data. According to Silver, as far as we know at this time, dosing for cats and dogs is the same.
Both Silver and Cital say patients can and do respond differently to standard dosages, perhaps because only animals with an endogenous deficiency in the endocannabinoid system respond to these products.
Most CBD given to pets at the present time is given orally. There are many other forms of CBD and routes of delivery (e.g., concentrates, topicals, transdermals, vaporizers, nebulizers, suppositories, capsules, tablets, soft chews, powders, biscuits, etc.), however, these are all still being studied in animals. Since bioavailability will be different for different routes, the recommendations for each will be different, and there are no guidelines yet.
Cital also notes that delivery either transdermally or via inhalation bypasses metabolism through the liver, so extra caution is warranted — especially since there is no research available yet in companion animals
CBD and Pain Relief in Pets
In Silver’s experience, lower doses of CBD are often effective for neuropathic pain, but higher doses are typically required to alleviate discomfort in dogs and cats with inflammatory conditions such as osteoarthritis.
Cital recommends starting with 1 to 2 mg/kg twice daily regardless of the source of the pain, and titrating (adjusting the dose up or down) to achieve the desired effect. He also noted that nonsteroidal anti-inflammatory drugs (NSAIDs) and CBD can act synergistically, so use of both may lower the necessary dose of either.
Silver and other veterinarians he’s in contact with have found 0.5 mg/kg twice daily to be effective. He feels it’s wise to start at this lower dose, which may prove effective, to reduce the cost and amount of hemp extract used. He also says that using CBD together with opioids may allow for lower opioid doses, because CBD indirectly stimulates opioid receptors
CBD and Seizures
Silver makes the point that since THC itself is psychotropic, it is not considered an anti-seizure drug and has been reported to actually cause seizures. If this is the case, any THC in a CBD could potentially make a seizure patient worse, but studies are incomplete.
He cites a Colorado State University study of CBD at 2.5 mg/kg twice daily for refractory epilepsy in which some dogs experienced a 40% reduction in seizures,4 which Silver considers a not-very-impressive result. In my opinion, if your pet is among the 40% of animals that improve, it’s quite impressive and worth exploring as an adjunctive treatment. A new study at a higher dose (4.5 mg/kg twice daily) is underway.
He says that for uncomplicated seizures that are either infrequent or well-controlled with anti-convulsant drugs, veterinarians and pet owners are finding that 0.5 to 1.0 mg/kg of CBD twice daily can control them and even allow for reduced doses of anti-epileptic drugs in some cases.
CBD and Cancer
Cannabinoids appear to be able to fight cancer. Studies are underway, including a 3-year study at the University of Guelph’s Ontario Veterinary College (OVC) to explore the use of cannabis to treat canine bladder cancer.5
Silver cautions that many claims surrounding CBD and cancer are, so far, not based in evidence, however, researchers have discovered the presence of receptors on tumor cells for cannabinoids. He knows of a veterinary oncologist who treated a lingual (tongue) mass using only non-THC CBD at 0.5 mg/kg twice daily, and in six weeks the mass was reduced to “nearly nothing.”
Silver is also aware of a dog with an appendicular fibrosarcoma (a cancerous tumor of the leg) whose owners didn’t want to amputate. Treatment with nutraceuticals (not containing CBD) kept the tumor from growing for a year, at which point it started to grow again. So the dog was started on a 1:1 CBD:THC product and within three months the tumor had shrunk “dramatically.”
In another case Silver is aware of, a dog with an undifferentiated nasal carcinoma with bone lysis (damage to the bone from the cancer) was treated with a non-THC CBD product (0.4 mg/kg twice daily), and the tumor shrunk significantly over six weeks of treatment. The dog was still in remission 14 months later.
Both humans and animals can develop tolerance to chronic use of certain cannabinoids, including THC. When it comes to cannabinoids for cancer, when the treatment is stopped, the cancer may recur, indicating the animal has developed tolerance to CBD products.
Silver believes it’s important to alert pet parents to this phenomenon. “If you get a tumor response and stop, it will come back, and it will come back resistant,” he warns.6 It is also suspected that secondhand smoke may create THC tolerance in animals, but further studies are needed.
Side Effects of CBD in Pets
According to Silver, elevations in alkaline phosphatase (ALP) levels (ALP is a liver enzyme) with CBD use have been consistently noted in studies, but the “why” has yet to be studied. Diarrhea is a common side effect of CBD in pets, but at the present time it doesn’t appear there are any long-term adverse effects associated with bloodwork or urinalysis.7
THC toxicity in pets is a significant problem. “Too often in Colorado people are getting adult medical marijuana and giving it to pets,” says Silver. “Human dosages of these drugs will send pets to the ER. Hemp products do contain THC and can cause typical signs of THC toxicity, but they are more mild effects.”8
One very important message for all pet parents: No human edibles. Edibles often contain substances that are toxic to pets, including chocolate, xylitol, and grape and raisin extracts.
Choosing a CBD Product
Out of the hundreds, perhaps thousands of brands of CBD on the market, how does a pet parent or veterinarian go about choosing a high-quality product?
Both Silver and Cital recommend that you request a certificate of analysis from the manufacturer that indicates potency, per-dosing unit, all ingredients, and the presence of mycotoxins, metals or pesticides to determine if a product is reasonably safe. At this time, many manufacturers don’t provide this information or offer only a limited version, but hopefully this will improve with time.
I have also found substantial differences in effectiveness and potency not only between brands, but lots/batches, so if you didn’t think a brand you tried was effective, I recommend doing more research and choosing a different brand.
It’s important to keep in mind that anything that sounds too good to be true usually is, but hopefully, CBD products will one day have evidenced-based science behind them to prove their significant medicinal value.
Marijuana Vs Hemp
Marijuana and hemp both come from the plant Cannabis sativa (though marijuana also comes from another member of the Cannabis family, Cannabis indica).
The cannabis plant has over 60 chemicals called cannabinoids. The two main types of cannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). CBDs are therapeutic cannabinoids, while THC is the cannabinoid that makes you high.
Marijuana’s THC content is usually between 10 and 15 percent; but hemp must have a THC content of 0.3 percent or less. At this level, cannabis has no intoxicating effect, for people or dogs.
Hemp is higher in CBD, the substance that provides the therapeutic effects.
How CBD Works
The cannabis plant contains a number of different chemicals, including CBD, phytocannabinoids, terpenoids and flavonoids. Humans and other mammals have specific cannabinoid receptor sites. These sites are primarily in the brain and central nervous system, and in peripheral organs, especially immune cells. They make up what’s called the endocannabinoid system.
Studies show that many cannabinoids have anti-inflammatory effects, and can help with pain, tumors, seizures, muscle spasms, skin conditions, appetite stimulation, aggression, anxiety and neurological disorders
How CBD Hemp Can Help Your Dog
CBD hemp can help with both chronic and acute disease.
Among chronic conditions, it can help with arthritis, compromised immune systems, stress responses, aggression and digestive issues. There are also studies under way into CBD’s effects on Type 1 diabetes, organ diseases and cancer.
Veterinarians are also finding CBD oil can be useful in treating acute ailments like sprains and strains, torn ligaments, bone breaks and even during post-operative care to reduce swelling, pain and stiffness.
If your dog’s taking conventional drugs for any of these conditions, CBD hemp may make it possible to use lower doses of the drugs to achieve therapeutic effects. Since conventional medicines do have side effects, this is a useful benefit of CBD.
Does It Work Fast?
As with any herbal medicine, for most ailments you may not see an immediate effect. You’ll need to be patient.
Your dog may feel some pain relief in a few hours but other symptoms like inflammation may take a few days to show improvement.
First of all, because of the low THC, CBD hemp won’t make your dog high.
The most common side effect of CBD is that your dog may get a little drowsy – about the same as if you gave him a Benadryl.
On rare occasions, side effects have included excessive itchiness or mild vomiting, but these sensitivities are few and far between. If your dog reacts with these symptoms, you should stop giving him cannabis.
If Your Dog Gets Into Marijuana
This article’s not about marijuana, but this is important information. With the legalization of marijuana in many places, poison control centers are hearing more and more about pets getting into their owners’ marijuana stash.
It may be hard to tell if your dog has the munchies (isn’t it a permanent condition in dogs?), but other side effects from marijuana can be quite severe, including lethargy, dilated pupils, drooling, being off balance, muscle twitching, vomiting, involuntary urination and even unconsciousness.
If this happens to your dog, take him to the vet immediately. He’ll need palliative support until the effects wear off.
Personally I always advise my clients to start with low dosages and work their way up to effect. Once you find the dose that your animal friend needs stay with it and adjust as you need for optimum effect.
I also ONLY recommend CBD oils that have been extracted from ORGANIC farmed plant material
I recommend 1 to 5 mg per 10 pounds of body weight daily depending upon the particular need of the patient. I recommend starting low and finding the optimum dosage needed by the patient over time. Usually within 3 days you will notice an improvement if the dose is what is needed. If not increase by ONE more mg/10 pounds of body weight and wait to see what the response is.
KEEP IT SIMPLE $$$$$$$$
I will give you a typical example of how you make a $ decision on a product once you have determined it to meet the purity and content requirements. When you have two exact bottles with 30ml of liquid CBD oil in them and they both cost $81.00, which one do you pick? Good question and worth taking a few minutes to learn the answer.
One bottle says 1000 mg/30 ml and the other says 2500 mg/30ml. NOW which one do you pick? Easy answer, the 2500 mg/30ml because it contains 2 1/2 times more mg. of CBD oil than the other. Sometime they mislead you on the bottles with so many mg/ per dose ( the dose may be a dropper full which varies from dropper to dropper). The best label says mg/drop and with this you know exactly what the dose is each time.
WHAT CBD oil extract does Dr. Blake use for his animal, human family and himself?
Make sure you enter this code blake10 to get a 10% discount when you order these amazing oils.
I also ONLY recommend CBD oils that have been extracted from ORGANIC farm sources and that is 99+% pure CBD oil and that it has been tested by an outside laboratory for purity, contaminates and has less than 0.1% THC.
WHEN YOU GET TO THE ORDER PAGE CLICK THE PULL DOWN AT THE TOP SHOP AND YOU WILL FIND ALL THE DIFFERENT CBD OIL EXTRACT PRODUCTS
Here is the last laboratory analysis by ProVerde Laboratories on Infinite CBD oil that I am using at this time. http://www.ProVerdeLabs.com